Stay up-to-date on the advancing field of HCT with short summaries and links to the most relevant published research.
Less HLA mismatching may provide better outcomes over haploidentical donor HCT in the setting of PTCy
Battipaglia G, et al. – Research published in Bone Marrow Transplantation finds that less HLA mismatching is associated with better overall survival, non-relapse mortality, and leukemia-free survival when comparing one-antigen mismatched unrelated donor hematopoietic stem cell transplant to haploidentical donor HCT in the presence of post-transplant cyclophosphamide.
Rapid donor identification improves survival in high-risk first-remission patients with Acute Myeloid Leukemia
John M. Pagel, MD, PhD, Megan Othus, PhD, et al – Barriers to human leukocyte antigen (HLA) typing and cytogenetic testing can significantly impact the overall survival of patients newly diagnosed with acute myeloid leukemia (AML). In this landmark study, a concerted effort to address those issues and streamline the initiation of donor identification and referral for hematopoietic cell transplant (HCT) consultation in early disease state led to a higher CR1 transplantation rate and improved 2-year overall survival.
Updated evidence-based guidelines for optimal selection of unrelated donors and cord blood units for HCT
Dehn J, et al., Blood – A panel of immunogeneticists and other experts in the field of hematopoietic cell transplantation (HCT) has published updated evidence-based guidelines for the optimal selection of unrelated donors and cord blood units used for transplants.
The updated guidelines make recommendations for both HLA and non-HLA factors to consider in graft selection, including donor availability, donor age, patient sensitivity to HLA antigens, natural killer (NK) cell alloreactivity, and minimum total nucleated cell doses and CD34+ cell doses for cord blood units.
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