HLA and Search Strategy
A successful transplant requires a high degree of human leukocyte antigen (HLA) match between the patient and donor or cord blood unit (CBU). Learn about the role of HLA in HCT, the latest HLA matching guidelines, and donor and cord blood search strategies.
HLA Overview: Antigens and Alleles
The HLA antigens are proteins found on the surface of most nucleated cells. The HLA proteins are encoded by genes called HLA alleles. The location on the chromosome where these genes are found is called the locus. Individuals express several types of locus specific HLA antigens, including:
- Class I antigens: HLA-A, -B, and -C
- Class II antigens: HLA-DR, -DQ, and -DP
HLA antigens play an important role in the immune system’s ability to identify self from non-self. The diversity of HLA alleles allows the immune system to combat the variety of potential pathogens it may encounter. Each person carries two alleles of each HLA gene, one inherited from their mother and one from their father.
HLA Basics and Matching Guidelines
- HLA Education Series
This series offers basic to advanced training on the role of HLA in cellular transplantation.
- HLA Typing Resources
Resources for general and specific information on human leukocyte antigen (HLA) typing.
- HLA Matching Guidelines
Understand NMDP and CIBMTR matching guidelines and criteria for selection of marrow, PBSC, and CBUs.
- Applying HLA Matching Guidelines
Review case studies to apply the latest HLA matching guidelines for HCT patient cell source selection.