Donor Selection Beyond HLA
Selection of Unrelated HCT Donors: Beyond HLA
HLA matching is the dominant controllable donor-recipient factor determining the outcome of adult unrelated donor hematopoietic cell transplantation (HCT). Beyond HLA, selection is often based on donor characteristics such as age, sex, parity, cytomegalovirus (CMV) serostatus, and ABO blood type. In addition, non-HLA donor factors that may influence donor availability can also affect donor selection and the timing of allogeneic transplantation.
This session will:
- Review published evidence on the role of non-HLA factors as determinates of survival
- Highlight new data regarding factors that may affect donor availability
- Describe efforts by the NMDP, and worldwide registries, to increase the availability of adult unrelated HCT donors
Traditional Perspective on Non-HLA Factors in Donor Search
Dennis L. Confer, M.D.
Chief Medical Officer
National Marrow Donor Program®
Creating a Donor Profile: The Likelihood of a Successful Search, Procurement and Transplant
Willis H. Navarro, M.D.
Medical Director, Transplant Services
National Marrow Donor Program
International Perspective on Donor Selection
J.A. Madrigal, M.D., Ph.D.
The Anthony Nolan Research Institute
The Anthony Nolan Trust