Basic Biology of HLA


Explore the basic biology of proteins, their functions and why matching is so important.

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Target Audience

NMDP/Be The Match Network partners, nurses, laboratory technologists, and other healthcare professionals who work in the field of marrow and cord blood transplantation. 

Learning Objectives

  1. Identify the Class I & II HLA proteins and their functions
  2. Describe the concept of polymorphic HLA proteins in regards to hematopoietic cell transplantation (HCT)
  3. Summarize the possible outcomes of patient/donor HLA protein mismatching


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Immunogenetic Operations & Research spearheaded the creation of the HLA education series with the help of Case Management and NMDP Education and Training. The Immunogenetic Operations & Research department is responsible for understanding the scientific aspects of hematopoietic cell transplantation data, ensuring the timely acquisition and validation of these data for searching patients, and translating the evolving science into actionable policies, practices, and services.